When exploring the landscape of advanced biochemical research tools, the abaloparatide peptide sequence stands out as a fascinating subject of study. As someone deeply interested in the structural nuances of synthetic analogs, I have spent significant time analyzing the molecular architecture of this specific peptide. Whether you are researching its structural properties or comparing it to other PTHrP-derived chains, understanding the fundamental amino acid arrangement is Abaloparatide, sold under the brand name Tymlos among others,is a parathyroid hormone-related protein (PTHrP) analogue medicationused to treat osteoporosis.Read more essential.
Structural Composition an abaloparatide. A 34amino acidsynthetic analog of human parathyroid hormone-related protein (PTHrP) (PTHrP(1-34) analog), with bone-growing and bone density Read more d Molecular Design
At its core, abaloparatide is a synthetic 34-amino acid peptide analog. Its design is derived from the human parathyroid hormone-related protein, specifically PTHrP(1-34). The primary objective in the development of this molecule was to create a stable, potent agent that effectively mimics the amino acid sequence of the first 34 residues of PTHrP.
The amino acid sequence is defined by a highly specific chain: Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His.
A notable feature of this amino-acid string is its homology. It possesses an amino acid sequence identical to that of PTH-related peptide in the first 20 amino acids, while incorporating strategic substitutions in the C-terminal region (positions 22–34) to optimize its stability and function. The inclusion of t 28 Apr 2017—The active substance ofAbaloparatideis synthesized using SPPS (Solid Phase.PeptideSynthesis) strategy with excellent optimized process Read more he non-proteinogenic amino acid 2-aminoisobutyric acid (Aib) at position 29 is a critical design choice that distinguishes it from endogenous proteins.
Technical Specifications and Identity
For those conducting laboratory analysis, the following parameters are often referenced:
* Molecular Formula: C174H300N56O49
* Molecular Weight: Approximately 39 Abaloparatide 3mg from manufacturer 60.59 Da
* Classification: It is a parathyroid hormone-related protein (PTHrP) analogue medication concept used in research to study bone-related signaling pathways.
* Synthesis Strategy: The peptide is typically produced using the Solid Phase Peptide Synthesis Abaloparatide - Ipsen/Paratek Pharmaceuticals - AdisInsight (SPPS) method, which allows for the high-fidelity assembly of these 34 residues.
Why the Sequence Matters
In the world of biochemistry, the sequence is everything. By modifying the C-terminal region of the native PTHrP molecule, researchers have created an amino acid peptide that interacts selectively with the PTH1 receptor. This specificity is why the abaloparatide structure is so frequently cited i It is a synthetic 34 amino acidpeptidewith 41% homology to human parathyroid hormone 1-34 and human PTHrP 1-34.Abaloparatideand PTHrP share the first 21 Read more n comparative studies against other analogs like teriparatide.
The Synthetic human PTH-related peptide analog containing 34 amino acids serves as a benchmark for how subtle changes in a protein chain can influence binding affinity and metabolic stability. When evaluating these materials for research, always ensure you are sourcing from providers that offer high-purity, standardized abaloparatide sequences verified by mass spectrometry and HPLC.
Personal Perspective on Research Utility
In my own experience reviewing various research materials, the precision required to synthesize this 34-residue chain is impressive. The abaloparatide molecule represents a masterful application of structure-activity relationship (SAR) studies. Because the amino acid sequenc Abaloparatide | C174H300N56O49 | CID 76943386 - PubChem e is so closely guarded and calculated, researchers must be diligent in verifying that the peptide received matches the expected PTHrP(1-34)-based profile.
For those diving into the literature, keep in mind that the sequence is not just a list of letters; it is a functional map. Whether you are analyzing its folding patterns or its interaction with receptor sites, the structural integrity of the amino acid chain is the foundation of your entire experiment. Always verify the sequence against the established CAS registry (247062-33-5) to ensure your data remains consistent with global research standards.