When exploring advanced skincare ingredients, I often find myself diving deep into the technical specifications of specific compounds. One molecule that frequently appears in discussions regarding anti-aging formulations is Acetyl Hexapeptide-8. As someone who values understanding the "why" behind product performance, I have spent considerable time researching the structural properties of this peptide, particularly its molecular weight.
Defining the Molecule: Acetyl Hexapeptide-8
Often referred to by the brand name Argireline, Acetyl Hexapeptide-8 is a synthetic peptide composed of six amino acids: Acetyl-glutamic acid, glutamic acid, methionine, glutamine, arginine, and arginine (Ac-EEMQRR-NH2). In my experience reviewing various suppliers and research documents, it is consistently identified as a white to off-white powder. Its chemical identity is formally classified und Argireline (Synonyms: Acetyl hexapeptide-3; Acetyl hexapeptide-8) ; Molecular Weight. 888.99 ; Color. White to off-white ; Sequence Shortening. Ac-EEMQRR-NH2. er CAS 616204-22-9.
Analyzing the Molecular Weight
The molecular weight of this compound is a critical metric for those of us i Molecular Weight: ~888.99 Da. • Solubility: Highly water-soluble due to its polar amino acid composition. • Stability: Stable under neutral pH and refrigerated nterested in how peptides interact with the skin barrier. Throughout my review of technical data sheets and scientific literature, the consensus for the molecular weight of Acetyl Hexapeptide-8 is consistently cited as app by J Zdrada-Nowak · 2025 · Cited by 12 — Due to its hydrophilic nature and relatively large molecular size, AH-8 faces limited permeability through the lipophilic stratum corneum, roximately 888.99 g/mol (sometimes rounded to 889.0 Da or 889.98 Da in specific studies).
While some older or variant data might show slight deviations—such as 887.0 g/mol or specific mass calculations like 888.42358458 g/mol—the value of 889.0 remains the industry standard for this hexapeptide. It is important to distinguish this from other peptide chains; for instance, I have encountered data for other peptides with a molecular weight of 3751.20, which highlights why one must be precise when verifying purity and identity.
Structural Characteristics and Considerations
The molecular formula for this specific acetyl hexa Molecular Formula. C35H62N14O11S ; Synonyms. Acetyl hexapeptide-3; Acetyl Hexapeptide-8; Argireline NP; Hexapeptide 3; L4EL31FWIL ; Molecular Weight. 887.0 g/mol. peptide-8 is widely documented as C34H60N14O12S. Its physical behavior is largely defined Mar 29, 2017 — M.W/Mr.
. 888.99
. Molecular Formula
. C46H56N12O6
. Description
. Acetyl hexapeptide-3 is a synthetic by this size and its chemical structure:
* Hydrophilicity: The peptide is known for being highly water-soluble due to its polar amino acid composition.
* Permeability: Because of its relatively large molecular weight (approx. 888.99), it faces challenges in penetrating the lipid-rich stratum corneum. This is a common topic in academic reviews, which often note that this size and hydrophilic nature pose barriers to transdermal delivery.
* Stability: In my personal storage practices, I have found that keeping it in a cool, dry environment—preferably at 2–8°C—is essential for maintaining the stability of the acetyl hexapeptide-8 powd Acetyl hexapeptide-8 er.
Practical Observations
When I source Acetyl Hexapeptide-8 for my personal research projects, I prioritize certificates of analysis that specify the 889.0 Da range. Observing the molecular weight allows me to better understand the formulation requirements. Since it is a hexapeptide with a specific molecular formula, it requires careful handling to ensure it remains effective in a final solution.
Whether you are looking into Acetyl Hexapeptide-8 products for their molecular profile or simply curious about the science behind the acetyl hexapeptide-8 label, understanding these fundamental constants—888.992 or 889.0—prov by PD Shank · 2020 · Cited by 2 — Acetyl Hexapeptide-8 has a molecular weight of 889.98 Da and an estimated octanol/water partitioning coefficient (log. Ko/w) of -7.68.6 ides a clear picture of the substance. It is a fascinating example of how a specific sequence of amino acids, when synthesized correctly, results in a distinct molecular weight that dictates its behavior in any given application.
By grounding my knowledge in these verifiable metrics, I can better evaluate the quality and potential of the acetyl hexapeptide-8 I encounter in the marketplace. As with any sophisticated chemical component, the value lies in the precision of the molecular data and the consistent quality of the raw material.