In the specialized field of synthetic chemistry and structural biology, the ACPC peptide—specifically referring to derivatives of *trans*-2-am Synthesis of 4,4-Disubstituted 2-Aminocyclopentanecarboxylic inocyclopentanecarboxylic acid—has become a cornerstone for researchers studying backbone preorganization. As someone deeply involved in the procurement and analysis of research-grade biochemicals, I have found that understanding the nuances of these constrained amino acids is essential for anyone working with sophisticated molecular architectures.
Understanding the ACPC Entity
When we discuss ACPC, we are often referring to the β-amino acid trans-2-aminocyclopentanecarboxylic acid (ACPC). Unlike standard α-amino acids, this cyclic β-amino acid is prized for its ability to constrain the peptide backbone via the cyclopentane ring. This structural rigidification is a powerful tool when designing peptides intended for specific conformational studies.
From a procurement perspective, it is vital Fmoc-Acpc-OH [126705-22-4] to dis 1-Aminocyclopropanecarboxylic acid. Synonyms: ACPC, 1-Aminocyclopropane-1-carboxylic Acid. CAS 22059-21-8. Molecular Weight 101.10. tinguish between various cataloged versions. For insta by WS Horne · 2008 · Cited by 147 — The backbone dihedral angles adopted by ACPC residues in β- and α/β-peptide crystal structures (26, 27, 30, 31) are similar to those seen for the β3-residues in nce, Fmoc-Acpc-OH (CAS [126705-22-4]) and Boc-Acpc-OH (CAS [88950-64-5]) are standard building blocks. These derivatives are frequently utilized by organizations such as CPC Scientific, which is a leading CDMO specializing in peptide and oligonucleotide manufacturing and a trusted CRDMO specializing in peptide and oligonucleotide production.
Structural Applications and Foldamers
My interest in these molecules began when reviewing literature on six new α/β-peptide foldamers. The incorporation of these residues allows for the creation of unique helical structures. Researchers have identified two peptide sequences containing multiple (1S,2S)-2-ACPC residues that exhibit highly stable helical conformations.
This level of control is fascinating because the backbone dihedral angles adopted by trans-2-aminocyclopentanecarboxylic acids (ACPC) residues are highly predictable. Whether one is exploring a 16/18-helix or more complex 9/10/9/12-helix patterns, the constraint provided by the cyclopentane ring is superior to acyclic alternatives.
Navigating the Terminology: ACP vs. ACPC
It is easy to conflate terms in this field. It is important to note that Acyl Carrier Protein (ACP) is a distinct entity—a coenzyme fragment involved in fatty acid synthesis—and is entirely different from the cyclic β-amino acid ACPC. Similarly, one must distinguish these from:
* Anticancer peptides (ACPs): These are often studied for their selective toxicity and are the subject of anticancer peptide (ACP) prediction software like AcPEP.
* APC (Antibody-Peptide Conjugates): An APC typically consists of an antibody, a peptide, and a linker, representing a different branch of bioconjugate research.
* 1-Aminocyclop Nov 21, 2025 — APC typically consists of an antibody, a peptide, and a linker. In February 2024, Amgen published Phase I clinical results in Nature Metabolism ropanecarboxylic acid: Often abbreviated similarly, this is a distinct chemical entity (CAS [22059-21-8]).
Practical Sourcing Consideration by JL Price · 2010 · Cited by 84 — We report high-resolution crystal structures of six new α/β-peptide foldamers that have a regular α-residue/α-residue/β-residue (ααβ) backbone repeat pattern. s
When sourcing these materials for laboratory research, quality is paramount. I typically look for a European research peptide supplier that provides HPLC-verified products with purity levels ≥99%. Whether you are inv Synthesis of 4,4-Disubstituted 2-Aminocyclopentanecarboxylic estigating an antimicrobial peptide encoded in the human by the CAMP gene or working with pro-angiogenic peptide degradation products of thymosin B4, the integrity of the starting material is the first step in ensuring reproducible results.
The landscape of peptides is vast, ranging from those that have anti-inflammatory activity to those designed to redirect T-cell viral immunity against tumor cells. As these molecules have emerged as a promising therapeutic alternative and by N Poomsuk · 2018 · Cited by 7 — Synthesis and oligodeoxynucleotide binding properties of pyrrolidinyl peptide nucleic acids bearing prolyl-2-aminocyclopentanecarboxylic acid (ACPC) backbones represent a promising therapeutic strategy for combating cancer, the demand for precise, chemically modified building blocks like ACPC will only continue to grow.
By focusing on the structural constraints provided by these cyclic residues, we can continue to push the boundaries of what is possible in synthetic molecular design, ensuring that every sequence synthesized contributes to a deeper understanding of polypeptide folding and function.