In the realm of biochemical research, the study of protein aggregation and structural biology relies heavily on high-purity synthetic molecules. One of the most frequently discussed subjects in laboratory settings is amyloid beta peptide 1-42 cas 107761-42-2. As someone who has spent considerable time sourcing high-quality peptides for in vitro studies, I have found that understanding the nuances of this specific peptide is essential for consistent experimental outcomes.
Technical Specifications and Identification
The amyloid beta 1-42 sequence is a 42-amino acid peptide derived from the proteolytic processing of a transmembrane protein, specifically the a This peptide corresponds to the CtoN inverted sequence of Beta-amyloid 1-42. CAS registry number. 317366-82-8. Molecular Formula. C203H311N55O60S.Read more myloid precursor protein (APP). When sourcing this material, the CAS Number: 107761-42-2 is the primary identifie β-Amyloid Peptide (1-42) (human) r used to ensure you are receiving the correct human-derived sequence.
From my experience, verifying the CAS regist Alternative Name.Amyloid-β(1-42).CAS. 107761-42-2. Formula. C203H311N55O60S. MW. 4550.18. Purity. ≥95%. Sequence.Read more ry details is the first step in quality control. The molecular weight is approximately 4514 g/mol, and researchers often look for a purity level of ≥95% as determined by HPLC. It is important to distinguish this from the inactive form, which is often identified by CAS No. 317366-82-8 (the 42-1 reverse se Beta-Amyloid (1-42) HFIP treated - Specifications · Purity: >95% (HPLC-MS) · Delivery Format: Freeze-dried in plastic vial ·CAS: 107761-42-2· Application(s): Read more quence).
Understanding the Entity and Variations
The amyloid β-peptide (1-42) human variant is the gold standard for many biophysical studies. However, researchers must be aware of species-speci β-Amyloid Peptide (1-42), human fic differences:
* Human: CAS 107761-42-2.
* Rat/Mouse: CAS 166090-74-0.
* Scrambled/Control: CAS 1678415-52-5.
The β-amyloid (1-42), human form is the most studied due to its propensity to aggregate, a process that is central to the pathology of Alzheimer's disease, making it a key focus for those investigating protein deposition mechanisms. When working with these materials, I always prioritize batches that are HFIP-treated to ensure the monomeric state of the peptide pri Apexbio Technology LLC Amyloid β-Peptide (1-42) or to the initiation of aggregation studies.
Practical Considerations for Research Use
When handling beta amyloid in the lab, storage is critical. Most suppliers recommend storing the lyophilized powder at -20°C. Because beta-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits, its handling requires precision.
The amyloid β peptide is notoriously sensitive to environmental conditions. If you are preparing samples, ensure you are using a consistent buffer system. The 1-42 length is particularly prone to forming fibrils compared to the 1-40 variant, which is a common point of comparison in literature. Whether you are using it for SPR (Surface Plasmon Resonance) or simple aggregation assays, the peptide must be kept on ice during preparation to maintain its integrity.
Conclusion
The study of amyloid proteins remains a cornerstone of modern biochemistry. By focusing on the correct CAS Number, 107761-42-2, and ensuring high-purity standards, researchers can better understand the complex nature of these molecules. Whether you are comparing amyloid beta 1-42 to its 1-40 counterpart or examining its structural properties, maintaining rigorous standards for your amyloid peptide samples is the most reliable way to ensure reproducibility in your findings. Always consult the Certificate of Analysis (CoA) provided by your supplier to confirm the specific CAS and purity metrics of your batch.