In the specialized field of biochemical research, identifying the correct molecular markers is essential for rigorous laboratory analysis. As a researcher who frequently sources high-purity biochemicals for in vitro studies, I have found that understanding the precise nomenclature and chemical properties of amyloid beta peptide 1-40 is critical for consistent experimental outcomes.
Technical Profile and Chemical Identity
When sourcing this material, the CAS number 131438-79-4 serves as the definitive identifier for the human version of this molecule. The amyloid beta sequence consists of 40 amino acids, derived from the larger amyloid precursor protein (APP) via sequential proteolytic cleavage by secretases.
For those analyzing the structural integrity of the peptide, it is important to note the following specifications:
* Molecular Formula: C194H295N53O58S
* Molecular Weight: Approximately 4330 Da
* CAS: 131438-79-4
* Purity Standards: High-quality batches typically require ≥95% purity as determined by HPLC.
Laboratory Handling and Preparation
One of the most significan beta-Amyloid Peptide (1-40) (rat/mouse) t challenges in working with amyloid materials is their tendency to form a CAS number. 131438-79-4; Form. Solid. See storage information ; Molecular weight. 4330 Da ; Molecular formula. C194H295N53O58S ; PubChem. 57339250 Read more ggregates. Many researchers prefer beta-Amyloid (1-40) TFA or variants treated with 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP). HFIP is frequently employed to break down pre-formed aggregates, ensuring the beta amyloid exists in a monomeric Amyloid Beta-Peptide(1-40) (human). Amyloid precursor proteinCAS# 131438-79-4.Amyloid Beta-Peptide(1-40) ( Read more state prior to the start of an experiment. This ensures a reproducible baseline, which is vital when studying the 1-40 fragment's behavior in controlled environments Amyloid Beta-Peptide (1-40), Human .
It is worth noting that the amyloid beta peptide is highly sensitive to storage conditions. If the material is not handled correctly, it can lose its structural characteristics. For comparative studies, some labs also utilize the rat/mouse equivalent, identified by CAS number 144409-98-3, which features a slightly different molecular mass of 4233.76 g/mol.
Distinctions in Research Applications
While discussing these peptides, it is common to encounter inquiries regarding the Amyl HFIP breaks down pre-formed aggregates and returnsbeta amyloid(1-40)peptides(CAS: 131438-79-4) to a monomeric state, ensuring a clean, reproducible starting Read more oid beta 1-42 variant. While they are similar, the 1-42 version contains two additional C-terminal residues (Ile41 and Ala42), which significantly impacts its aggregation kinetics. When I review recombinant peptide Beta-Amyloid 1-40, I focus on its role as a primary component in research models focusing on neurodegenerative pathways.
The amyloid β fragment is not just a single entity; it is a complex subject of study. Researchers often utilize a beta-Amyloid (1-40 Specific) Antibody to validate the presence of these amyloid peptides in Western Blot (WB) or ELISA assays. This level of verification is standard practice for those working with beta amyloid peptide to ensure that the results are specific to the 1-40 sequence.
Summary for Lab Procurement
When managing laboratory inventory, always verify the CAS Number, 131438-79-4 on the certificate of analysis provided by the supplier. Whether you are dealing with amyloid in powder form or a specialized PEPTIDE solution, maintaining the cold chain and utilizing proper reconstitution buffers is essential. Because this beta-protein is a 40-43 amino acid peptide, its stability is highly dependent on the CAS-verified purity and the absence of contaminants.
By adhering to these rigorous standards and keeping detailed records of the Cas No.: 131438-79-4 for every lot, researchers can ensure their work involving amyloid beta remains consistent and reproducible across various developmental stages of their study. Always remember that these materials are intended exclusively for research The Amyloid β Peptide (Aβ1-40) Is Thermodynamically purposes and require handling Amyloid Beta-Peptide (1-40) (human) by trained personnel in a controlled laboratory setting.