In the realm of biochemical research and synthetic biology, few molecules have garnered as much interest for targeted delivery studies as Angiopep-2. As someone deeply invested in peptide synthesis and laboratory-grade reagents, I have followed the evolution of this molecule closely. Understanding the p Angiopep-2 Supplier | CAS 906480-05-5 recise angiopep-2 peptide sequence is fundamental for anyone looking to explore its unique properties in controlled settings.
Chemical Composition and Structural Integrity
Angiopep-2 is a 19-amino-acid synthetic peptide with the sequence TFFYGGSRGKRNNFKTEEY. This specific sequence is derived from the Kun The peptide sequence binds to receptors overexpressed on cancer cells, allowing the drug to be directly released at the cancer site. Peptides designed to bind itz domain of human aprotinin, a discovery that revolutionized how researchers approach receptor-mediated interactions.
From a technical standpoint, the molecular weight of this peptide is approximately 2,301.5 g/mol, with a chemical formula of C104H149N29O31. When evaluating the quality of a peptide sample, I always look for high-purity standards, typically ≥95% as determined by HPLC. It is important to note that Angiopep-2 is a 19-amino-acid synthetic peptide that is commonly linear in structure, which allows for specific modifications, Angiopep-2 Modification such as the addition of a cysteine residue to create an Angiopep-2-Cys peptide for site-specific conjugation.
Why the Sequence Matters
The functionality of this molecule is inextricably linked to its primary structure. The sequence—Thr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-Tyr—is optimized to specifically interact with low-density lipoprotein receptor-related protein 1 (LRP1). This high affinity is what makes it a subject of intense study for those interested in complex molecular transport.
Variations of the molecule, such as the Angiopep-2-azide peptide, are frequently utilized in sophisticated bioconjugation experiments. In my experience, maintaining the integrity of this sequence is vital; even minor deviations can impact the binding efficacy to the target receptor.
Technical Considerations for Laboratory Use
When sourcing this material, researchers often encounter Angiopep-2 hydrochloride, which is a brain peptide vector widely recogni A novel LRP1-binding peptide L57 that crosses the blood zed for its stability and solubility. Proper storage is paramount—I strictly adhere to keeping samples at -20°C to prevent degradation.
Key technical specifications for the Angiopep-2 sequence include:
* Sequence: TFFYGGSRGKRNNFKTEEY
* Structure: 19-mer synthetic peptide
* Origin: Derived from the Kunitz domain of human aprotinin
* Target: LRP1 receptors
It is also worth noting that the peptide sequence binds to receptors overexpressed on cancer cells in various in vitro models, which is why it has become a staple in advanced laboratory platforms. Whether you are working with Angiopep-2 (Ang-2) conjugated to nanoparticles or studying it as a standalone peptide, the precision of the synthesis is the most critical factor.
Final Observations
The study of peptide sequences like Angiopep-2 represents a fascinating intersection of chemistry and structural biology. By utilizing a 19-amino acid sequence that is highly specific for LRP1, researchers have gained a powerful tool for exploring targeted interactions.
As a reminder, all such materials are strictly for lab use only and are not for human use. By focusing on the structural nuances of the Angiopep-2 peptide, we can continue to push the boundaries of biochemical research, ensuring that every e Jan 4, 2023 — ANG was synthesized according to the solid-phase synthesis method, and the peptide sequence of ANG was as follows: TFFYGGSRGKRNNFKTEEY. (22) We xperiment is grounded in reliable, high-quality data. Whether you refer to it as Angiopep 2 or by its full sequence, the rigor app Angiopep-2 | C104H149N29O31 | CID 134687501 - structure, chemical names Sequence. TFFYGGSRGKRNNFKTEEY. PLN. H-TFFYGGSRGKRNNFKTEEY-OH. HELM. PEPTIDE1 lied to its handlin Angiopep-2 as an Exogenous Chemical Exchange Saturation g remains the foundation of successful scientific inquiry.