In the specialized field of biochemical research, the apelin 36 peptide stands out as a subject of intense scientific scrutiny. As someone who has long followed the development of bioactive compounds, I have watched the evolution of this molecule from its i Apelin-36, human [252642-12-9] nitial identification in bovine stomach extracts to its current status as a significant focus in laboratory investigations. By examining the available data, we can gain a clearer understanding of why this specific sequence remains a cornerstone in modern peptide research.
Understanding the Molecular Identity of Apelin-36
At its core, apelin 36 is a mature 36-amino acid peptide derived from a 77-amino acid prepropeptide. Encoded by the *APLN* gene in humans, it serves as the endogenous ligand for the G-protein-coupled APJ receptor. The structural complexity of this molecule, represented Predictive Value of Apelin-36 for the No-Reflow by the sequence H-Leu-Val-Gln-Pro-Arg-Gly-Ser-Arg-Asn-Gly-Pro-Gly-Pro-Trp-Gln-Gly-Gly-Arg-Arg-Lys-Phe-Arg-Arg-Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH, highlights its unique role in cellular signaling pathways.
For rese Catalog Number: P001253. Synonym:Apelin-36, human. CAS Number: [252642-12-9]. Molecular Weight: 4195.92. Molecular Formula: C184H297N69O43S Read more archers, sourcing high-quality apelin 36, human is critical. Many laboratories rely on a global supplier of Apelin-36 (Human) to ensure the purity and consistency required for sensitive assays. Whether you are performing ELISA, Western Blot, Dot blot, or PCA, the quality of the peptide is paramount. It is important to note that products labeled as Apelin-36(human) TFA are strictly for laboratory research use only.
Biological Functions and Research Applications
The scientific community has extensively documented that Apelin-36 has been linked to two major types of biological activities: cardiovascular regulation and metabolic homeostasis. As an endogenous APJ receptor agonist (with an EC50 of approximately 20 nM), its influence on physiological systems is profound.
Cardiovascular and Neurological Insights
One of the most compelling aspects of this molecule is its ability to modulate cardiac function. Research indicates that the substance protects the heart against ischemia-reperfusion injury in vivo by activating the Reperfusion Injury Salvage Kinase (RISK) pathway. Furthermore, studies have shown that apelin-36 promotes neurological function recovery after ischemic brain injury, often by ac On Methods for the Measurement of the Apelin Receptor tivating the PI3K/Akt pathway, which demonstrates anti-apoptotic activity. In controlled experimental models, it has even been observed that decreased infarct size in vitro by 39.6% in specific testing environments.
Metabolic and Systemic Roles
Beyond the heart and brain, the apelin peptide is widely expressed in various organs, including the adipose tissue, kidneys, liver, and gastrointestinal tract. Its role in lowering blood pressure, regulating heart and blood vessel contraction, and influen Apelin-36 cing insulin secretion makes it a versatile tool for studying metabolic diseases. Recent advancements have introduced modified versions, such as Apelin-36-[L28A] and Apelin-36-[L28C(30kDa-PEG)] peptides, which are being investigated for their potential to improve diet-induced obesity by acting as biased ligands at the APJ receptor.
Practical Considerations for Research Use
When conducting experiments, it is essential to distinguish between the native peptide and its various isoforms. For instance, Apelin is an endogenous peptide that is cleaved into several bi Apelin-36(human) TFAinhibits the entry of some HIV-1 and HIV-2 into the NP2/CD4 cells expressing APJ. For research use only. We do not sell to patients. Custom Read more ologically active forms. Researchers interested in molecular characteristics, biological functions, and signaling efficacy often compare apel Apelin-36 in-36 with shorter isoforms like apelin-13 or pyr-13.
Additionally, the apelin 36 peptide has shown intriguing properties in virology research, specifically as it inhibits HIV-1 entry in cells coexpressing CD4 and the APJ receptor. This multifaceted profile—ranging from cardiovascular protection to viral entry inhibition—ensures that it remains a high-interest molecule for future discovery.
Conclusion
The study of the apelin 36 peptide continues to yield valuable insights into the fundamental mechanisms of cellular signaling. Whether one is evaluating its capacity for reduced cerebral infarct volume in a laboratory setting or analyzing its role as an APJ receptor agonist, the precision of these studies relies on high-grade materials and rigorous methodology. As research progresses, the ongoing investigation into these peptides will undoubtedly continue to expand our understanding of the APLN-APJ signaling axis.
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*Disclaimer: This article is for informational purposes only. Full-length matureapelin peptide; acts primarily in the regulation of cardiovascular function, fluid homeostasis, hypertension, and insulin sensitivity; Read more The substances discussed are for laboratory re Predictive Value of Apelin-36 for the No-Reflow search use and are not intended for human consumption or medical use.*