In the field of biochemical research, the CD47 peptide sequence remains a focal point for those investigating molecular interactions at the cell surface. CD47, often referred to as integrin-associated protein (IAP) or MER6, is a transmembrane protein that in humans is encoded by the CD47 gene. As a researcher and enthusiast in the field of synthetic biology, I have spent significant time analyzing the structural nuances of this molecule, which is a ubiquitously expresse by T Zhang·2024·Cited by 22—CD47 is a heavily glycosylated protein with six potential N-linked glycosylation sites at asparagine residues23, 34, 50, 73, 111, and 206(sequences containing Read more d membrane protein.
Structural Insights and the CD47 Peptide Sequence
When we look at the molecular architecture, it is important to understand that CD47 is a 40–60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. CD47, a Ligand for the Macrophage Fusion Receptor Its complexity is further highlighted by its N-linked glycosylation, with critical sites identified at positions 23, 34, 50, 73, 111, and 206.
From a synthetic perspective, researchers often rely on specific fragments to study binding affinities. One of the most common sequences utilized in laboratory settings is:
GNYTCEVTELSREGKTVIELK
This specific custom CD47 peptide containing the sequence of “GNYTCEVTELSREGKTVIELK” is frequently synthesized for use in lipid nanoparticle research and binding assays. It provides a reliable model for exploring how these domains interact with their environment.
Another notable region often explored is the N-terminal fragment. Researchers frequently use a sy CD47 Blocking Peptide (A56129). Validated Applications: Immunodepletion and Immunocompetition. Available as 250µg. ✔️ 100% Quality Guarantee. nthetic peptide taken within amino acid region 100-150 on human CD47 protein, characterized by the sequence:
FKGRDIYTFD GALNKSTVPT DFSSAKIEVS QLLKGDASLK MDKSDAVSHT
Understanding the CD47/SIRPα Pathway
The interest in these sequences stems largely from the CD47/SIRPα pathway, an a by TE Papp·2025·Cited by 31—Custom CD47 peptide containing the sequence of “GNYTCEVTELSREGKTVIELK”was synthesized by LifeTein. Micelles containing the CD47 peptide were incorporated into Read more rea of intense study in contemporary molecular biology. The CD47 molecule is a transmembrane glycoprotein, which, like MFR, belongs to the superfamily of immunoglobulins. The long isoform precursor of this protein contains 323 amino acid residues, providing a substantial framework for various cellular interactions.
When discussing the primary sequence, it is essential to distinguish between different research applications. For instance, the CD47 Blocking Peptide (A56129 An in-situ peptide-antibody self-assembly to block CD47 ) is a standard tool for those looking to perform immunodepletion or immunocompetition experiments. My experience with these materials suggests that purity and the verification of the correct sequence are paramount for consistent results.
Observations on Sequence Variations
The structural-functional diversity of CD47 proteoforms is largely dictated by the precise amino acid arrangement. Whether you are searching for the full sequence in a database or working with a truncated synthetic version, the sequence identity remains a critical variable.
For those conducting in-depth analysis, tracking the specific sequence of interest is vital. Whether you are using the “GNYTCEVTELSREGKTVIELK” variant or examining the broader 323 amino acid structure, understanding the underlying biology of CD47 is a fascinating journey. As this field continues to evolve, the ability to synthesize and manipulate these specific peptide CD47Binder: Identify CD47 Binding Peptides by segments remains a cornerstone of modern experimental design, allowing for a more granular understanding of how these markers function at the interface of cellular systems.