In the field of biochemical research, the CD47 peptide sequence remains a focal poi CD47 Blocking Peptide (A56129). Validated Applications: Immunodepletion and Immunocompetition. Available as 250µg. ✔️ 100% Quality Guarantee. nt for those investigating molecular interactions at the cell surface. CD47, often referred to as integrin-associated protein (IAP) or MER6, is a transmembrane protein that in humans is encoded by the CD47 gene. As a researcher and enthusiast in the field of CD47, His, Human syn CD47 molecule - Homo sapiens (Human) | UniProtKB thetic biology, I have spent significant time analyzing the structural nuances of this molecule, which is a ubiquitously expressed membrane protein.
Structural Insights and the CD47 Peptide Sequence
When we look at the molecular architecture, it is important to understand that CD47 is a 40–60 kDa variably glycosylated atypical member of the immunoglobulin superfamily. Its complexity is further highlighted by its N-linked glycosylation, with critical sites identified at positions 23, 34, 50, 73, 111, and 206.
From a synthetic perspective, researchers often rely on specific fragments to study binding affinities. One of the most common sequences utilized in laboratory settings is:
GNYTCEVTELSREGKTVIELK
This specific custom CD47 peptide containing the sequence of “GNYTCEVTELSREGKTVIELK” is frequently synthesized for use in lipid nanoparticle research and binding assays. It provides a reliable model for exploring how these domains interact with their environment.
Another notable region often explored is the N-terminal fragment. Researchers frequently use a synthetic peptide taken within amino acid region 100-150 on human CD47 protein, characterized by the sequence:
FKGRDIYTFD GALNKSTVPT DFSSAKIEVS QLLKGDASLK MDKSDAVSHT
Understanding the CD47/SIRPα Pathway
The intere CD47, also known as IAP or MER6,is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 gene belongs to the immunoglobulin superfamily. st in these sequences stems largely from the CD47/SIRPα pathway, an area of intense study in contemporary molecular biology. The CD47 molecule is a transmembrane glycoprotein, which, like MFR, belongs to the superfamily of immunoglobulins. The long isoform precursor of this protein contains 323 amino acid residues, providing a substantial framework for various cellular interactions.
When discussing the primary sequence, it is essential to distinguish between different research applications. For instance, the CD47 Blocking Peptide (A56129) is a standard tool for those looking to perform immunodepletion or immunocompetition experiments. My experience with these materials suggests that purity and the verification of the correct sequence are paramount for consistent results.
Observations on Sequence Variations
The structural-functional diversity by D Hazama·2020·Cited by 65—These peptides harbor an R(F/Y) (S/T) (A/P)Vsequencemotif, bind to mouse SIRPα with KD values in the low nanomolar range (~10–60 nM), and Read more of CD47 proteoforms is largely dictated by the precise amino acid arrangement. Whether you are searching for the full sequence in a database or working with a truncated synthetic version, the sequence identity remains a critical variable.
For those conducting in-depth analysis, tracking the specific sequence of interest is vital. Whether you are using the “GNYTCEVTELSREGKTVIELK” variant or examining the broader 323 amino acid structure, understanding the underlying biology of CD47 is a fascinating journey. As this field continues to evolve, the ability to synthesize and manipulate these specific peptide segments remains a cornerstone of modern experimental design, allowing for a more granular understandi 16423 - Gene ResultCd47 CD47 antigen (Rh-related ng of how these markers function at the interface of cellular systems.