When exploring the world of synthetic peptides for research purposes, the DAMGO structure peptide stands out as a foundational tool for laboratory investigations. As someone deeply invested in the study of receptor-ligand interactions, I have spent considerable time analyzing the chemical architecture of this specific molecule. Its significance in biochemical research cannot be overstated, particularly when examining how synthetic analogs interact with cellular components.
The Chemical Foundation of DAMGO
At its core, DAMGO (often referred to as H-Tyr-D-Ala-Gly-N-MePhe-Gly-ol) is a synthetic pentapeptide. Its design is derived from the endogenous opioid DAMGO | potent μ opioid receptor agonist peptide met-enkephalin. The primary reason research Damgo | C26H35N5O6 | CID 5462471 - PubChem - NIH ers utilize this specific compound is that DAMGO is a highly selective agonist for the mu opioid receptor. By incorporating D-amino acids, the peptide gains metabolic stability, 8EFQ: DAMGO-bound mu-opioid receptor-Gi complex which is a common strategy in peptide engineering to resist rapid degradation in experimental environments.
The molecular identity of the compound is defined by the Formula, C26H35N5O6. When reviewing the DAMGO P DAMGO - an overview eptide Structure, it is clear that the modification at the second position (D-Ala) and the N-methylation of the phenylalanine residue at the fourth position are critical. These structural nuances are what allow it to maintain such high affinity for its target.
Structural Analysis and Receptor Binding
In my personal review of the available literature, the structures of the mu-opioid receptor (μOR) in complex with this ligand provide a fascinating look at molecular docking. Specifically, the cryo-electron microscopy (cryo-EM) data has unveiled how the peptide DAMGO fits into the binding pocket.
The precision of the molecule is best understood by its chemical nomenclature: H-Tyr-D-Ala-Gly-N-MePhe-Gly-ol. This s DAMGO, a mu-opioid receptor selective ligand equence ensures that the ligand remains a highly selective peptide agonist for the μ opioid receptor. Because it distinguishes so effectively between receptor types, it has become a standard reference material in ligand activity charts.
Key Characteristics and Experimental Use
For those who manage a laboratory inventory, maintaining the integrity of these peptides is paramount. The standard protocol for Damgo involves storage at -20°C to prevent hydrolysis or structural degradation.
Key technical specifications include:
* Molecular Weight: 513.7 g/mol
* Purity: Typically >95% for high-grade research applications
* CAS Number: 78123-71-4
* Classification: Synthetic mu-opioid receptor selective ligand
Reflections on Peptide Research
My experience with DAMGO, a mu-opioid receptor selective ligand, has shown me that the beauty of this molecule lies in its specificity. Whether one is studying the GPCR (G-protein-coupled receptor) signaling pathways or investigating the structural basis of receptor targeting, DAMGO is a highly selective peptide agonist for the μ opioid receptor. Product Specifications for DAMGO. Molecular Weight. 513.70. Formula. C26H35N5O6. Storage. this peptide serves as a benchmark.
While many researchers compare it to other compounds like Dermorphin or Dadle, the unique structure of DAMGO remains the gold standard for μOR studies. It is important to note that this information is intended for educational and laboratory research contex DAMGO | Ligand Activity Charts ts only. The precision of the DAMGO (H-Tyr-D-Ala-Gly-N-MePhe-Gly-OH) sequence is a testament to the advancements in peptide synthesis, allowing us to probe the complexities of transmembrane signaling with unmatched accuracy.
As the field of structural biology continues to evolve, the data derived from these high-affinity ligands will undoubtedly continue to play a pivotal role in our understanding of molecular recognition and cellular signaling.