In the rapidly evolving world of biochemical research, enthusiasts and scientists alike often encounter complex nomenclature that can be confusing. A frequent point of discussion involves the distinction between DY 131 peptide and oth SS‐31, a Mitochondria‐Targeting Peptide, Ameliorates er mitochondrial-targeting agents. As someone deeply interested in the m Feb 2, 2016—Elamipretide (MTP-131), a novel mitochondria-targetingpeptide, was shown to reduce infarct size in animals with myocardial infarction and Read more echanics of cellular research, I have spent significant time reviewing the literature to clarify what these compounds are and how they function in experimental models.
Clarifying the DY 131 Compound
It is important to start with a clear definition. When researchers discuss DY-131, they are generally referring to a small molecule rather than a traditional peptide. DY131 (GSK 9089) is a potent and selective ERRγ and ERRβ agonist. Unlike some other compounds often grouped under the same research umbrella, DY-131 is a small molecule that acts as an estrogen-related receptor agonist.
In laboratory settings, DY 131 is frequently utilized for its ability to modulate energy metabolism, mitochondrial biogenesis, and cellular signaling pathways. Specifically, it is used to potentiate ERRγ-induced growth inhibition in various cell line studies. Because of its selectivity, it is often preferred in experiments where researchers need to target specific receptors while avoiding activity at ERRα, ERα, or ERβ.
Distinguishing DY 131 from Mitochondrial by A Karaa·2018·Cited by 185—Elamipretideincreased exercise performance after 5 days of treatmentin patients with PMM without increased safety concerns.Read more Peptides
A common point of confusion arises because of the naming conventions used in scientific databases. While DY 131 is a small molecule agonist, many people searching for it inadvertently find information regarding elamipretide (MTP-131), also frequently searched as SS-31.
It is vital to distinguish between these two:
* DY 131 is a small molecule ERRβ/γ agonist.
* SS-31 (Elamipretide) is a tetrapeptide—a short chain of amino acids.
SS-31 is a synthetic tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that is a unique tetrapeptide that specifically targets the mitochondria within cells. It is a tetrapeptide with a cationic 3+ charge at physiological pH, which allows it to pass through cell membranes and localize within the inner mitochondrial membrane.
The Role of Mitochondrial-Targeted Research
Research into Elamipretide (SS-31, MTP-131) has gained significant traction due to its interaction with cardiolipin. MTP-131 is a cell-permeable peptide that preserves the integrity of cardiolipin, a vital lipid component of the mitochondrial membrane. By stabilizing this structure, SS-31, a mitochondria-targeting antioxidant, helps maintain the efficiency of the electron transport chain.
In various animal and in vitro models, this Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, has shown the ability to modulate energy metabolism and assist in scenarios where mitochondrial function is compromised. For instance, studies have explored its potential in supporting cardiac health and protecting against oxidative stress. It is worth noting that Elamipretide (MTP-131, SS-31) is currently an investig by HH Szeto·2014·Cited by 232—Bendavia (MTP-131), a movel mitochondria-targetingpeptide, normalizes expression of cardiolipin remodeling genes and proteins in left ventricular Read more ational drug being developed to treat mitochondrial diseases, and it has even shown promising results in trials where it increased exercise Peptide SS-31 upregulates frataxin expression and performance after 5 days of treatment.
Why Context Matters in Research
When reviewing data, always verify the chemical nature of the substance. 131 is a number that appears in both the small molecule DY-131 and the peptide MTP-131. Because the peptide (SS-31) is a small peptide that accumulates in mitochondria, it is often studied for its protective effects, whereas the small molecule (DY-131) is primarily studied for its role in receptor-mediated signaling, such as its role as an agent that suppresses by H Zhao·2017·Cited by 77—In our study, we demonstrated that treatment with the mitochondrion-targetedpeptideSS-31 reduced frataxin deficiency-induced oxidative stress Read more growth and proliferation of prostate, esophagus, gastric and breast cancer cells in specific experimental conditions.
For those looking into these compounds for personal research interest, it is essential to rely on peer-reviewed literature. Whether you are investigating the signaling pathways of ERRβ/γ or the protective properties of mitochondrial-targeted tetrapeptides, maintaining a clear distinction between these entities ensures that your data interpretation remains accurate and scientifically sound.
Understanding the specific mechanism of action—whether a compound acts as a receptor agonist or a membrane-stabili Elamipretide (aka Bendavia, MPT-131, and SS31)is a tetrapeptide with a cationic 3 + charge at physiological pHthat is currently in clinical development Read more zing peptide—is the fo Elamipretide: Uses, Side Effects, Dosage undation of rigorous biochemical inquiry. As research continues to advance, the distinction between these specialized molecules will remain a key focus for those navigating the complexities of mitochondria Elamipretide (aka Bendavia, MPT-131, and SS31)is a tetrapeptide with a cationic 3 + charge at physiological pHthat is currently in clinical development Read more l and cellular biology.