In the specialized field of biochemical research, the Gap27 peptide has emerged as a significant tool for investigators studying cellular communication. As a synthetic co The Connexin Mimetic Peptide Gap27 and Cx43 nnexin43 mimetic peptide, it provides a highly specific method for modulati Gap 27 | 198284-64-9 | Connexin43 mimetic peptide ng gap junction channels, which are essential for maintaining homeostasis and signaling between adjacent cells.
What i by WH Evans·2007·Cited by 190—Recent examples include studies showingGap27 inhibiting intercellular communicationand antigen cross presentation in dendritic cells (Matsue et al., Citation Read more s the Gap27 Peptide?
Gap27 is a peptide derived from connexin 43, specifically corresponding to the amino acid sequence SRPTEKTIFFI (amino acids 204–214) found on the second extracellular loop of the protein. Because it mimics a portion of the native protein, it acts as a selective inhibitor. When researchers utilize this compound, they are essentially employing a gap junction blocking peptide to study the mechanisms of intercellular communication.
For those interested in the technical specifications, the molecular weight of this substance is approximately 1304.5 Da. It is often categorized alongside other synthetic peptid Cardiac remodeling and arrhythmogenesis are es like Gap26 and Gap27, which have been instrumental in laboratory settings for over two decades.
Mechanisms and Research Applications
The primary utility of this compound lies in its ability to target specific connexin proteins. Unlike broader inhibitors, Gap27 inhibits the formation of gap junctions and GJIC (gap junctional intercellular communication) with high selectivity.
My interest in this area began with reviewing how Gap27 is a small synthetic connexin mimetic peptide that allows for precise control over experimental conditions. For example, studies have observed that Gap27 inhibits intercellular communication and antigen cross-presen The Connexin Mimetic Peptide Gap27 and Cx43 tation in various cell cultures. Furthermore, Gap27 can be effective in promoting the healing of superficial epithelial wounds in controlled *in vitro* environments, highlighting its versatility in tissue-related research.
Distinct Variations: Cx43 vs. 40Gap27
It is important to distinguish between the standard Cx43-targeting variant and other specialized sequences. For instance, the connexin mimetic peptide 40GAP27 is specifically designed for the Cx40 domain. Research indicates that while Gap27 is a synthetic connexin-mimetic peptide for Cx43, the 40-variant serves as a connexin mimetic peptide 40GAP27 that does not regulate Cx43, demonstrating the high specificity required when working with these molecules.
Key Considerations for Researchers
Wh by V Abudara·2014·Cited by 226—Synthetic peptides like Gap26 and Gap27that mimic a short stretch of amino acids (AAs) on the extracellular loops have been developed more than two decades Read more en sourcing this peptide, purity and validation are paramount. Whether you are investigating inhibition connexin 43 by mimetic peptide Gap27 or exploring its effects on cell migration, the quality of the compound directly impacts the reproducibility of the data.
* Chemical Identity: Often cross-referenced by CAS number 198284-64-9.
* Specificity: Known as a Cx43 mimetic peptide Gap27, it is essential to ensure the sequence matches your specific experimental model.
* Experimental Scope: Whether you refer to it as GAP-27, GAP27, or peptide4 (Gap27), the underlying function remains a critical subject of inquiry for those observing cellular signaling dynamics.
Fin Sep 17, 2025—Gap 27 is a synthetic peptidedesigned to modulate intercellular communication by targeting connexin43 (Cx43), a predominant gap junction Read more al Thoughts
The study of peptides—specifically those that modulate protein channels—continues to provide deep insights into how cells interact. As a researcher, viewing Gap 27 as a synthetic peptide designed for targeted inhibition allows for a cleaner experimental design. By focusing on the precise sequence homology of the second extracellular loop, investigators can achieve more reliable results in their exploration of gap junctional complexes.
*Disclaimer: This content is for informational purposes related to laboratory research only. It does not provide medical, prescription, or human use advice.*