In the world of biochemical research and peptide analysis, few molecules command as much attention as the glucagon-like peptide 2 (GLP-2). As a user interested in the structural nuances of these compounds, I have spent considerable time examining the sequence and chemic Sequence: Ala. A. His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile Dissolve the peptide in 100 µl of DMSO or 60% acetonitrile in water with 0.1 Read more al properties that de Glucagon Like Peptide 2 Receptor - an overview fine this fascinating molecule. Whether you are reviewing literature on the GLP2R gene or exploring how glucagon-like peptide 2 (GLP-2) receptors function, understanding the primary structure is the foundational step.
The Primary Structure: Decoding the Sequence
The human glucagon-like peptide 2 is a 33-amino acid peptide, and its specific HADGSFSDEMNTILDNLAARDFINWLIQTKITD alignment is critical to its biological identification. When sourcing or analyzing this material, you will often see it r by W Sun·2020·Cited by 58—Its endogenous ligand isGLP-2(GLP-2(1–33)), a member of the glucagon-likepeptidefamily that also includes GLP-1 and glucagon.GLP-2is Read more epresented as HADGSFSDEMNTILDNLAARDFINWLIQTKITD-OH, which highlights the terminal hydroxyl group.
For those comparing laboratory data, the single letter sequence, HADGSFSDEMNTILDNLAARDFINWLIQTKITD, is the standard nomenclature. If you are looking at the three-letter code, it begins with H-His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu, GLP-2 (human) is an endogenous peptide identified as an intestinal Single Letter Sequence, HADGSFSDEMNTILDNLAARDFINWLIQTKITD. Storage, Store at -20°C.Read more reflecting the specific order of residues. This unique sequence is what distinguishes it from its counterpart, GLP-1, even though both are derived from the proglucagon gene.
Comparative Analysis and Structural Context
When I look at a sequence alignment of GLP-2 and related peptides, it becomes clear why this molecule is so unique. It GLP-2is related insequencetoGLP-1, glucagon, GIP and other members of the glucagonpeptidesuperfamily. Many of these peptides exhibit an alanine at Read more shares a heritage with the 29-amino-acid sequence of glucagon. In fact, researchers often discuss how GLP-2 is a newly discovered gastrointestinal peptide that operates within a complex superfamily.
It is important to note the differences between species:
* Human GLP2: Defined by the 33-residue HADGSFSDEMNTILDNLAARDFINWLIQTKITD chain.
* Mouse/Rat variants: These often show slight variations, such as at residue 11 or 19.
* GLP2: Often confused with other compounds in the GLP superfamily, it is distinct in its Glucagon-like peptide 2 is a 33- or 34-amino acid peptide located at the Sequence.H-His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-AsnRead more physiological role compared to the more commonly discussed GLP-1.
Technical Specifications for Research
For those involved in high-purity peptide handling, the molecular weight is approximately 3766.2 Daltons, with a molecular formula Sequence Shortening,HADGSFSDEMNTILDNLAARDFINWLIQTKITD; Molecular Formula, C165H254N44O55S ; Molecular Weight, 3766.2 ; Purity, > 95% ; Solubility, Soluble in Read more of C165H254N44O55S. When reviewing technical data, ensure the sequence: Ala. A. His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile is verified against the certificate of analysis for any sample you are evaluating.
Storage and Handling:
* Always store at -20°C or below to maintain integrity.
* Solubility is typically achieved in DMSO or 60% acetonitrile in water with 0.1% TFA.
* Purity levels should reflect >95% via HPLC to ensure the results of your sequence analysis are accurate.
Insights into the GLP2R Receptor
The interaction between the peptide and the glucagon-like peptide 2 receptor is a sophisticated mechanism mediated by G proteins, which activate adenylyl cyclase. This receptor, encoded by the GLP2R gene, is highly specific. When studying glucagon-like peptide 2 (GLP-2) receptors, it is common to see them grouped with other members of the glucagon-like peptide receptor family.
Final Thoughts on Personal Research
My personal experience with these compounds has taught me that precision is paramount. Whether you are using the H-His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile fragment or the full-length 33-mer, verifying the sequences against established databases is essential. The complexity of these 2 related molecules continues to provide deep insights into biological signaling, and as long as one focuses on the verifiable, technical aspects of the peptide, the depth of knowledge available is truly immense. Always prioritize high-quality, verified documentation when working with these sophisticated chains.