In the realm of biochemical research and synthetic biology, the study of regulatory proteins has led to a fascination with specific sequences that ma Hepcidin-25(human) | C113H170N34O31S9 | CID 90472084 intain systemic Hepcidin is a cationic,cysteine-rich and tightly folded peptidestabilized by 4 disulfide bonds that plays a major role in innate immunity and iron homeostasis.Read more balance. Among these, the hepcidine peptide formule—often discussed in scientific literature as Hepcidin-25—stands out as a subject of intense investigation. As someone who follows advancements in peptide research, I have found that understanding the structural integrity and the specific molecular formula C113H170N34O31S9 is essential for any serious enthusiast or researcher.
The Structural Architecture of Hepcidin
When we look at the Human Hepcidin-25 peptide, we are observing a fascinating piece of biological engineering. At its core, Hepcidin is a cationic, cysteine-rich and tightly folded peptide. This structural configuration is not accidental; it is stabilized by four distinct disulfide bonds, which grant the molecule its characteristic robustness.
The journey of this molecule begins as an 84-amino acid preprohepcidin. Through a series of highly regulated enzymatic cleavages, it is processed into mature peptides of 20, 22 and 25 amino acids. The 25-amino acid variant is widely considered the most biologically active form. It is important to note that hepcidin is predominantly synthesized and released by hepatocytes, the primary functional cells of the liver.
Defining the Role of LEAP-1
You may often see this substance referred to as LEAP-1 (liver-expressed anti by WI Leong·2004·Cited by 171—A newly identified iron regulator,hepcidin, appears to communicate body iron status and demand for erythropoiesis to the intestine, and in turn, modulates Read more microbial peptide). This synonym highlights its historical discovery as an antimicrobial agent. However, contemporary research has shifted the focus toward its role as a 25-amino acid peptide hormone.
In the broader context of systemic physiology, hepcidin is a liver-derived peptide hormone that acts as the central regulator of iron homeostasis. It functions by interacting with ferroportin—the primary cellular iron exporter—effectively modulating how the body manages systemic iron traffic. Because hepcidin is a hormone that regulates how your body uses iron, it is a frequent topic in studies involving iron metabolism.
Technical Specifications and Data
For those analyzing the technical aspects, the peptide is characterized by the following parameters:
* Molecular Formula: C113H170N34O31S9
* Molecular Weight: Approximately 2789.4 g/mol
* Structural Composition: Hepcidin-25(hepatic bactericidal protein), also known as LEAP-1 (liver-expressed antimicrobial peptide) is predominantly expressed in the liver.Read more Highly folded, cysteine-rich sequence
Researchers utilizing Hepcidin/LEAP-1 (Human) in laboratory settings often source high-purity synthetic versions. When reviewing Hepcidin 25 peptide documentation, you will find that it is typically stored at -20°C to maintain stability. The precision required to synthesize a molecule of this complexity—given its specific disulfide bridge requirements—is a testament to modern s by HN Hunter·2002·Cited by 652—The antibacterial and antifungalpeptide hepcidin(LEAP-1) is expressed in the liver. This circulatingpeptidehas recently been found to also act as a Read more ynthetic chemistry.
Personal Observations on Peptide Research
From my perspective as an enthusiast of high-quality peptides, the most intriguing aspect of this molecule is its precision. Whether you are reviewing Hepcidin-25 for structural biology or as a reference standard in mass spectrometry, the consistency of the formula is vital.
While many are familiar with the 25-amino acid peptide hormone as a concept, the actual hands-on verification of C113H170N34O31S9 in a controlled Purity: Synonym(s): Hepc25.Formula: Molecular Weight: MDL Number: Product description. Properties. Shelf life: 730 days. Solubility: Sensitivity:.Read more research environment provides a much deeper appreciation for its role in biology. As hepcidin continues to be studied, it remains a cornerstone for understanding how complex signa Aug 18, 2008—Hepcidin is a25-amino acid peptide(see left) secreted by the liver hepcidin expression in the presence of certain inflammatory cytokines.Read more ling molecules maintain equilibrium at the cellular level.
***
*Disclaimer: This article is for informational purposes only and reflects personal research and interest in peptide chemistry. It does not provide medical advice, diagnosis, or treatment recommendations. Always consult with qualified professionals regarding biological research or health-related inquiries.*