In the realm of biochemical research and synthetic biology, the lanreotide peptide sequence represents a fascinating study in molecular design. As a synthetic cyclic octapeptide analogue of somatostatin, lanreotide has garnered significant interest for its unique structural properties and its ability to undergo self-assembly into nanotubes.
The Structural Architecture of Lanreotide
Lanreotide is a synthetic polypeptide analogue of somatostatin that mimics the native hormone's biological activity. Structurally, it is defined by its precise amino acid sequence, which consists of eight residues. Specifically, the peptide sequence is categorized as: D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2.
A critical feature of this molecule is the disulfide bridge that connects the two cysteine residues, locking the structure into a stable β-hairpin conformation. This LAN is a well-preorganized peptide scaffold, which is essential for its functional efficacy. Researchers often note that the molecule contains three aromatic amino acids in a total of eight, which contributes significantly to its hydrophobic core and its propensity for supramolecular organization.
Technical Parameters and Composition
When analyzing the lanreotide structure, it is helpful to look at its chemical classification. It is a peptide, specifically falling under the definition of molecules composed of between three and ten alpha-amino acids joined by peptide bonds.
* Chemical Formula: C54H69N11O10S2
* Molecular Weight: Approximately 1096.3 g/mol
* Key Characteristics: The sequence includes aliphatic side chains—one hydrophobic (Val) and one hydrophilic (Thr)—which, alongside its aromatic components, drive the self-assembly properties of specific amino acid sequences.
Research Conte Molecular Origin of the Self-Assembly of Lanreotide into xt and Observations
In my personal experience reviewing analytical data regar Lanreotideis a medication used in the management of acromegalyand symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome.Read more ding synthetic peptides, the distinction between lanreotide and related somatostatin analogues like Lanreotide(Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate, an analog of the native Read more octreotide is often found in their cyclic backbones and specific side-chain co Peptide SequenceClick here for help. ACYWKVCT. D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2. Chemical Modification. Disulphide bond between cysteine residues at Read more nfigurations. While both are used in the managemen Lanreotide is a somatostatin These are organic compounds containing a sequence ofbetween three and ten alpha-amino acids joined by peptide bonds.Read more t of acromegaly and are recognized as a class of artificially synthesized growth hormone inhibin analogues, the specific lanreotide peptide sequence is highly optimized for its controlled-release characteristics.
The study of these peptide sequences is paramount for understanding how small changes in the amino acid sequence can alter the stability or the self-assembly profile of the final product. For instance, altering a single amino acid's configuration within the chain can compromise the integrity of the scaffold, highlighting the importance of high-purity synthesis.
Summary of Findings
The LANREOTIDE molecule remains a cornerstone in peptide chemistry research. Its ability to form crystalline nanotubes through self-assembly is a direct result of its carefully balanced sequence, which facilitates the segregation of hydrophobic and hydrophilic regions. Whether one is investigating the molecular origins of these structures or exploring the synthesis of sequences for research purposes, the technical precision required for handling such an octapept Categorised products for chemical name Lanreotidewith structure, catalogue number, CAS data, formula, weight and enquiry access. ide used in the treatment of acromegaly (in therapeut Lanreotide acetate synthesis and purification methods ic contexts) is immense.
For those interested in identifying high-quality materials, there are many categorised products for chemical name Lanreotide available for laboratory use. Always ensure that the analytical documentation, such as HPLC or MS data, confirms the sequence integrity to avoid common issues like deletion sequences or incomplete peptide chains. Understanding the fundamental nature of this peptide allows researchers to better appreciate the complex supramolecular structures it can form under controlled experimental conditions.