As an enthusiast of peptide research and molecular biology, I have spent significant time analyzing the structural complexities of synthetic compounds. One of the most fascinating molecules in this field is the linaclotide peptide sequence. Its unique archi 12 May 2021—Linaclotideis an orally administered peptide drugfor the treatment of irritable bowel syndrome with constipation (IBS-C) and abdominal pain.Read more tecture makes it a subject of great interest for those studying peptide synthesis and structural stability.
The Structural Identity of Linaclotide
Linaclotide is a 14-amino acid by NB Emidio·2021·Cited by 44—Linaclotide is14 amino acid residues longand is a designed hybrid of these three peptides (Figure 1A). Similar to STa, linaclotide holds three disulfide bonds Read more synthetic peptide that has garnered attention due to its specific configuration. When reviewing the primary literature, it is consistently identified as a fourteen-membered heterodetic cyclic peptide. This classification is crucial for researchers, as the ring structure is maintained by precise chemical bonding.
The official amino acid sequence is documented as: H–Cys1–Cys2–Glu3–Tyr4–Cys5–Cys6–Asn7–Pro8–Ala9–Cys10–Thr11–Gly12–Cys13–Tyr14.
In the laboratory, observing this 14-amino acid sequence reveals why it is categorized as a 14-amino-acid synthetic cyclic peptide. The stability of the molecule is largely at by NB Emidio·2021·Cited by 44—Linaclotide is14 amino acid residues longand is a designed hybrid of these three peptides (Figure 1A). Similar to STa, linaclotide holds three disulfide bonds Read more tributed to its three intramolecular disulfide bonds, which connect specific cysteine residues (C1–C6, C2–C10, and C5–C13).
Key Characteristics and Synthesis
From a technical perspective, the linaclotide sequence contains three inter-cysteine loops, which are integral to its functional geometry. When evaluating high-purity samples, researchers often look for the 14-amino acid residue peptide structure that ensures the molecule remains intact under various conditions.
1. Molecular Formula: C59H79N15O21S6
2. Molecular Weight: Approximately 1,526.8 Da
3. Structural Integrity: The 14 amino acid residues long chain relies on these specific disulfide bridges to maintain its potency and selective interaction with receptors.
During the manufacturing phase, the use of linaclotide linear peptide resin is a standard method for solid-phase synthesis. This process allows for the precise assembly of the 14-amino-acid peptide before the cyclization steps are performed to lock the structure into its final, stable form.
Observations on Peptide Research
In my personal experience, the study of LINACLOTIDE highlights the importance of regioselective synthesis. Because linaclotide is a synthetic peptide drug, maintaining the correct disulfide bridge placement is non-negotiable. If the bonds are misaligned, the structural properties of the 202811Orig1s000 - accessdata.fda.gov 14-amino acid synthetic peptide sequ Linaclotide - StatPearls - NCBI - NIH ence change significantly, rendering the molecule ineffective for its intended research applications.
Many researchers who work with this molecule note that linaclotide is a potent and selective guanylate cyclase C agonist. While it is technically an orally administered peptide drug in specific pharmaceutical contexts, those of us in the private research sector focus primarily on its 14-residue structure and its behavior in controlled environments.
Summary of Findings
To summarize, for anyone analyzing the linaclotide peptide sequence, it is essential to focus on:
* The precise H–Cys1–Cys2–Glu3–Tyr4 start of the chain.
* The 14-amino-acid synthetic cyclic peptide arrangement.
* The structural requirement for the three disulfide bridges that give linaclotide its distinct shape.
Whether you are synthesizing the molecule from linaclotide linear peptide resin or co A New Regioselective Synthesis of the Cysteine-Rich nducting structural analysis, the amino acid sequence provides the blueprint for this complex, cysteine-rich molecule. By adhering to these structural parameters, one can better understand why this 14-amino acid residue peptide remains a cornerstone of moder Linaclotideis a potent and selective guanylate cyclase C agonist; developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) n peptide science.