In the evolving landscape of advanced laboratory research materials, few compounds have garnered as much interest as the P 114 peptide. Known formally as Oligopeptide P11-4, this molecule represents a sophisticated leap in material scienc Oct 28, 2023 — P11-4 is a synthetic biomaterial composed of short peptides that can spontaneously assemble into nanofibrous scaffolds, mimicking the e. As someone who follows developments in synthetic biology and chemical research, I have found the technical profile of this substance to be particularly fascinating.
What is P 114 Peptide?
At its core, the P Appearance:solid ; Color:White ; Description. Oligopeptide P11-4 acetate is a peptide ; Molecular Weight, 1655.75 ; Formula, C74H102N20O 114 peptide is a rationally designed synthetic peptide of 11 amino acids. It is categorized as a synthetic, pH controlled self-assembling peptide, which is a mouthful for a truly elegant mechanism. When placed in specific environments—typically triggered by changes in pH or ionic strength—this peptide undergoes a structural transformation. It organizes itself into a hierarchical, three-dimensional network of β-sheet tapes, ribbons, fibrils, and fibers.
This ability to transition from a liquid state into a hydrogel-like scaffold is what makes it a synthetic biomaterial composed of short peptides. Because of these unique physical properties, Oligopeptide P11-4 has become a subject o Oligopeptide P11-4 is an α-peptide that can be self-assembled into β-sheet amyloids with a hydrogel appearance at low pH. f intense scrutiny in biomimetic research.
Technical Specifications and Chemical Profile
For those reviewing the technical documentation, it is essential to distinguish between various forms. Oligopeptide P11-4 acetate is a peptide that typically appears as Jun 16, 2021 — The SAP P11-4 forms a hydrogel with a three-dimensional network structure in specific environments that are influenced by changes in pH value or ionic strength. a white solid. Its molecular weight is approximately 1655.75 g/mol, with a complex chemical formula (C74H1 Effectiveness of Self-Assembling Peptide (P11-4) in Dental 02N20O).
The P11-4 peptide is often discussed alongside its variant, Self-assembling peptide P 11 -4F. These molecules are amphiphilic, meaning they possess both hydrophilic and hydrophobic characteristics, allowing them to interact with aqueous environmen Oligopeptide P11-4 acetate(593266-60-5 free base) ts in ways that facilitate structural integrity.
Research Applications and Observations
My interest in P11-4 stems from its role in laboratory-based studies focusing on The authors, including researchers from CareQuest Institute, concluded that self-assembling peptide P11-4 is a “promising treatment for initial caries lesions” surface interactions. The self-assembling peptide P11-4 is frequently explored for its utility in biomimetic mineralization, enamel regeneration, and oral care agent development.
In controlled environments, researchers have noted that self-assembling peptide P11-4 enhances remineralization of early carious lesions by permeating the porous surface and providing a scaffold for mineral deposition. When I look at the data, it is clear why this is a focus of study: P11-4 promoted the regeneration of incipient caries-like lesions in various in vitro models.
Furthermore, when comparing efficacy, studies often show that P11-4 was significantly more effective than the control group, particularly when considering measurements like the Ca/P ratio and Surface Micro-Hardness (SMH). The integration of P 11 -4 in combination with fluoride application is another area where researchers have observed synergistic effects, as the fluoride acts to support the mineral ions that the self-assembling peptide (SAP) P11-4 helps organize.
Personal Perspective on the Material
While the literature often references Oligopeptide-104 or Curolox® as synonymous or related technologies, the specific focus on P11-4 remains the gold standard for many experimental models. Whether researchers are looking at adhesion and whitening effects of P11-4 self-assembling peptide or investigating the self-assembling peptide P 11 -4 for its unique structural properties, the consistency of the results is striking.
It is important to note that this is a peptide intended for research purposes. As a user, I always ensure that any Oligopeptide P11-4 peptide sourced is for legitimate investigative work, as the self-assembling peptide used in oral care by SM Khairy · 2025 · Cited by 1 — CPP-ACPF presented superior antibacterial effect when compared to P11-4 with fluoride or NaF which exhibited comparable antibacterial effect. research requires high-purity standards. The Self- assembling peptide p11-4 is a prime example of how molecular engineering can mimic biological processes to achieve structural repair in non-living dental models.
Final Thoughts
The P-series peptides, specifically the P11-4, continue to demonstrate why they are considered a cornerstone of modern biomimetic research. From its ability to form a hydrogel to its role in facilitating hydroxyapatite deposition, the P11-4 is a remarkable tool for anyone interested in the intersection of chemistry and material science. As research continues to advance, I expect to see even more innovative applications for this versatile peptide.