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palmitoyl pentapeptide 4 sequence Pal-Lys-Thr-Thr-Lys-Ser

Published October Oct 17, 2026 6:20 PM

When exploring the world of advanced cosmetic ingredients, one name consistently surfaces in high-performance formulations: Palmitoyl Pentapeptide-4. For those of us who prioritize ingredient integrity in our personal care routines, understanding the structural composition of this molecule is essential. Often recognized by its commercial designation, Matrixyl, this bioactive compound has earned its reputation as a cornerstone in topical aesthetics.

Decoding the Chemical Structure

The effectiveness of this ingredient lies in its specific sequence. Biochemically, it is a synthetic peptide where a palmitoyl group—a long-chain fatty acid—is chemically linked to a pentapeptide sequence. This lipophilic modificat Palmitoyl Pentapeptide-4, a synthetic peptide compound, is renowned for its role in promoting skin health and rejuvenation. ion is crucial because it enhances the molecule's ability to interact with the skin's surface, improving overall delivery and efficacy.

The primary amino acid string defining this Palmitoyl Pentapeptide-4 is lysine-threonine Palmitoyl Pentapeptide 4 -threonine-lysine-serine. In scientific literature and technical data sheets, you will frequently see this represented Palmitoyl Pentapeptide-4 (Matrixyl) as Pal-Lys-Thr-Thr-Lys-Ser-OH or the abbreviated form, Pal-KTTKS.

Key technical specifications include:

* CAS Number: 214047-00-4

* Molecular Formula: C39H75N7O10

* Molecular Weight: Approximately 802.05 g/mol

* Standard Nomenclature: Pal-Lys-Thr-Thr-Lys-Ser

Biological Signaling and Function

Why is this specific Palmitoyl Pentapeptide so highly regarded? It functions as a "sign Palmitoyl pentapeptide 4 al peptide." Research suggests that it acts as a precursor sequence fragment of type I collagen. By mimicking the structure of natural skin components, it stimulates collagen production, which is why it is widely celebrated for its role in promoting skin health and rejuvenation.

It is important to note that while the standard Palmitoyl Pentapeptide-4 is associated with the KTTKS sequence, some studies indicate it is associated with two sequences, KTTKS and KTSKS, depending on the specific synthesis profile. This versatility highlights why it is a synthetic cosmetic ingredient widely used in skincare products across the globe.

Person Palmitoyl Pentapeptide-4 (Matrixyl) al Experience and Application

214047-00-4. Appearance. Solid. Color. White to off-white. Sequence. {Pal}-Lys-Thr-Thr-Lys-Ser. Sequence Shortening. {Pal}-KTTKS. Shipping. Room temperature in 

From my experience integrating this into my routine, I have found that the stability of the Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH complex makes it a reliable addition to any topical regimen. Because it is a small, biologically active molecule, it does not require complex delivery systems to be effective.

When searching for products containing this ingredient, you wi Safety Assessment of Myristoyl Pentapeptide-4, Palmitoyl ll often see it listed as {Pal}-Lys-Thr-Thr-Lys-Ser. Whether you are looking for a concentrated serum or a sophisticated cream, the presence of Palmitoyl Pentapeptide 4 ensures that the formula is designed with a focus on skin texture and resilience.

Final Thoughts for Enthusiasts

As someone who meticulously reviews ingredient lists, I find the precision of Palmitoyl Pentapeptide-4 to be fascinating. It is a testament to how synthetic chemistry can mirror natural processes to support the skin's architecture. Whether you refer to it by its full chemical name, Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH, or its shorthand Pal-KTTKS, it remains a gold standard in the industry for those pursuing a disciplined approach to skincare.

Always ensure you are sourcing your products from reputable manufacturers who adhere to high purity standards, as the efficacy of this 4-series peptide is highly dependent on the quality of the synthesis. By focusing on proven ingredients like this, you can better navigate the crowded landscape of modern cosmetic science.

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