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palmitoyl pentapeptide 4 sequence is a synthetic peptide where a palmitoyl group is chemically linked to a pentapeptide sequence

Published October Oct 17, 2026 6:41 PM

When exploring the world of advanced cosmetic ingredients, one name consistently surfaces in high-performance formulations: Palmitoyl Pentapeptide-4. For those of us who prioritize ingredient inte Palmitoyl Pentapeptide-4. Article No.: 2542100. Product Group: Cosmetic Product. Sequence: Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS). Product form: Lyophilized Powder. grity in our personal care routines, understanding the structural composition of this molecule is essential. Often recognized by its commercial designation, Matrixyl, this bioactive compound has earned its reputation as a cornerstone in topical aesthetics.

Decoding the Chemical Structure

The effectiveness of this ingredient lies in its specific sequence. Biochemically, it is a synthetic peptide where a palmitoyl group—a long-chain fatty acid—is chemically linked to a pentapeptide sequence. This lipophilic modification is crucial because it enhances the molecule's ability to interac Sequence Shortening. Palmitoyl-KTTKS-OH. Sequence. Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH. Length (aa). 5. Peptide Purity (HPLC). 95.29%. Molecular Formula. C39H75N7O  t with the skin's surface, improving overall delivery and efficacy.

The primary amino acid string defining this Palmitoyl Pentapeptide-4 is lysine-threonine-threonine-lysine-serine. In scientific literature and technical data sheets, you will frequently see this represented as Pal-Lys-Thr-Thr-Lys-Ser-OH or the abbreviated form, Pal-KTTKS.

Key technical specifications include:

* CAS Number: 214047-00-4

* Molecular Formula: C39H75N7O10

* Molecular Weight: Approximately 802.05 g/mol

* Standard Nomenc Palmitoyl Pentapeptide 4 is a powerful synthetic peptide widely used in premium skincare formulations due to its remarkable anti-aging and skin-rejuvenating  lature: Pal-Lys-Thr-Thr-Lys-Ser

Biological Signaling and Function

Why is this specific Palmitoyl Pentapeptide so highly regarded? It functions as a "signal peptide." Research suggests that it acts as a precursor sequence fragment of type I collagen. By mimicking the st Safety Assessment of Myristoyl Pentapeptide-4, Palmitoyl ructure of natural skin components, it stimulates collagen production, which is why it is widely celebrated for its role in promoting skin health and rejuvenation.

It is important to note that while the standard Palmitoyl Pentapeptide-4 is associated with the KTTKS sequence, some studies indicate it is associated with two sequences, KTTKS and KTSKS, depending on the specific synthesis profile. This versatility highlights why it is a synthetic cosmetic ingredient widely used in skincare products across the globe.

Personal Experience and Application

From my experience integrating this into my routine, I have foun Palmitoyl Pentapeptide; PAL-KTTKS; CAS 214047-00-4 d that the stability of the Palmit EWG's Skin Deep® database gives you practical solutions to protect yourself and your family from everyday exposures to chemicals in personal care products. oyl-Lys-Thr-Thr-Lys-Ser-OH complex makes it a reliable addition to any topical regimen. Because it is a small, biologically active molecule, it does not require complex delivery systems to be effective.

When searching for products containing this ingredient, you will often see it listed as {Pal}-Lys-Thr-Thr-Lys-Ser. Whether you are looking for a concentrated serum or a sophisticated cream, the presence of Palmitoyl Pentapeptide 4 ensures that the formula is designed with a focus on skin texture and resilience.

Final Thoughts for Enthusiasts

As someone who meticulously reviews ingredient lists, I find the precision of Palmitoyl Pentapeptide-4 to be fascinating. It is a testament to how synthetic chemistry c The amino acid sequence of the peptide is lysine–threonine–threonine–lysine–serine (KTTKS). Sometimes, it's also called collagen pentapeptide, as it's a  an mirror natural processes to support the skin's architecture. Whether you refer to it by its full chemical name, Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH, or its shorthand Pal-KTTKS, it remains a gold standard in the industry for those pursuing a disciplined approach to skincare.

Always ensure you are sourcing your products from reputable manufacturers who adhere to high purity standards, as the efficacy of this 4-series peptide is highly dependent on the quality of the synthesis. By focusing on proven ingredients like this, you can better navigate the crowded landscape of modern cosmetic science.

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