When exploring advanced biochemical research, one frequently encounters the term pt 161 peptide, often conflated with various synthetic compounds in literature. It is essential to clarify that in scientific databases, the primary subject of interest is ATN-161, a well-documented five-amino acid peptide that serves as a focal point for researchers studying cell signaling and receptor dynamics.
The Biochemical Profile of ATN-161
ATN-161 is a non-RGD based integrin binding peptide derived from the synergy region of fibronectin. Its chemical structure, often noted as Ac-PHSCN-NH2, makes it a specialized tool for laboratory investigations. Unlike standard RGD motifs, this small peptide antagonist of integrin alpha5beta1 interacts specifically with the N-terminus of the beta-1 region, which is a critical area of focus for those analyzing angiogenesis and cellular migration.
As someone who tracks peptide research, I find the specificity of the PHSCN peptide (licensed as ATN-161) to be particularly fascinating. It acts as an alpha v beta 1 inhibitor and is recognized as a novel int ATN 161 has been shown to inhibit tumour growth, angiogenesis and metastasis and extend survival in multiple animal tumours, it has also shown activity outside egrin alpha5beta1 antagonist. Because it selectively binds to and blocks the receptor for integrin, it has been a frequent subject in studies regarding the inhibition of tumor growth, angiogenesis, and metastasis.
E-E-A-T and Research Integrity
When reviewing data on The Integrin Binding Peptide, ATN-161, it is vital to rely on peer-reviewed literature and high-quality chemical suppliers. Many of the studies cited in academic repositories, such as PubMed, underscore the importance of purity and structural integrity in Inhibition of α5β1 Integrin With the Small Peptide ATN-161 these compounds. Whether you are looking at the Bcl-2-like protein 11 142-161 or the SHBG141–161 peptide, the nomenclature can be confusing. However, ATN 161 is a α5β1 integrin receptor antagonist that remains distinct from other epitope markers.
Key Technical Specif ATN-161 Peptide Functionalized Reversibly Crosslinked Squaric acid mediated synthesis and biological activity of a library of linear and hyperbranched poly( ications
* Molecular Composition: Five-amino acid s by BJ Beddingfield · 2020 · Cited by 90 — ATN-161, an integrin binding peptide, inhibits the interaction between the SARS-CoV-2 spike protein and its host binding partners. equence (Ac-PHSCN-NH2).
* Primary Function: Integrin receptor antagonism (specifically α5β1 and αvβ3).
* Research Application: Investigated for antiangiogenic properties and cell adhesion inhibition.
* Synthesis: Often produced via squaric acid-mediated synthesis in ATN-161 peptide functionalized revers by ME Cianfrocca · 2006 · Cited by 225 — Abstract: To evaluate the toxicity, pharmacological and biological properties of ATN-161, a five -amino-acid peptide derived from the synergy region of ibly crosslinked materials.
Observations on Experimental Use
In my experience analyzing laboratory reports, the distinction between ATN-161 and other compounds with "161" in their name—such as Tb-161 (a radionuclide) or MAGE-1 Antigen (161-169)—is paramount. A Phase 1 Trial of the Antiangiogenic Peptide ATN-161 highlighted its poten Nov 18, 2007 — ATN-161 is a non-RGD based integrin binding peptide targeting alpha-5 beta-1 and alpha-v beta-3. It inhibits the migration and adhesion of tial in modulating biological pathways, yet it is crucial to remember that these are strictly for controlled research environments.
The Integrin-binding peptide ATN-161 is freq (PDF) Phase 1 Trial of the Antiangiogenic Peptide ATN-161 uently utilized in murine models to evaluate its capacity to reduce liver metastasis. Its role as a non-competitive inhibitor of the fibronectin synergy site is what sets it apart from traditional antagonists.
Conclusion
Whether you are a student of biochemistry or a researcher focusing on cellular signaling, understanding the nuance of ATN-161 is key. It is not merely a number; it is a meticulously designed five amino acid peptide, ATN 161, that provides significant value in the study of integrin-mediated processes. Always ensure that when sourcing these materials, you prioritize suppliers who provide comprehensive HPLC analysis to confirm the identity and purity of the peptide. By focusing on the verified mechanisms of this small peptide antagonist of integrin alpha5beta1, we can better appreciate the complex nature of protein-protein interactions in experimental settings.