When navigating the complex world of biochemical research tools, specifically regarding the RGD peptide, accuracy in identification is paramount. As an enthusiast who frequently sources high-purity compounds for laboratory studies, I have found that distinguishing between specific sequences is vital. A common point of confusion for researchers is the variation in the CAS number associated with these molecules, as different sequences carry distinct identifiers.
Distinguishing Between RGD Variants
The term RGD (Arg-Gly-Asp) refers to a specific tripeptide sequence involved in cell adhesion. However, when you search for an RGD peptide, you will often encounter two primary CAS numbers, each representing a unique chemical entity.
1. The Tripeptide (Arg-Gly-Asp): This is the core sequence. The most frequently cited CAS No. 99896-85-2 refers to this simple tripeptide. With a molecular weight of 346.34 Da and a molecular formula of C12H22N6O6, it is a staple in studies focused on integrin-binding inhibition. When I look for RGD [99896-85-2] in catalog RGD (Arg-Gly-Asp) Peptides | CAS:99896-85-2 s, I prioritize sources that provide purity levels of >95% via HPLC.
2. The Hexapeptide (GRGDNP): A more complex variation often used in experimental models is the RGD peptide (GRGDNP). Its CAS Number 114681-65-1 is distinct from the tripeptide. This molecule, with a molecular weight of 614.61 and a molecular formula C23H38N10O10, is frequently employed as a potent inhibitor of integrin-ligand interactions.
Practical Considerations for Researchers
When you buy these materials, the CAS identifier acts as your primary safeguard against ordering the wrong sequence. I have Orbiton Life Sciences Private Limited - Offering Rgd Peptide,CAS No. 99896-85-2, Packaging Type: Vial, Packaging Size: 100 mg at ₹ 3000/box in Chennai, often seen researchers struggle when they confuse the CAS No. 114681-65-1 with the simpler CAS number 99896-85-2.
In my experience, storage i RGD Peptide (trifluoroacetate salt) s just as critical as identification. For instance, the RGD tripeptide is generally stable when kept at -20°C, but one must always verify the specific CAS No. documentation provided by the supplier. Some specialized, high-affinity peptides might require even lower temperatures or specific solvent conditions to maintain structural integrity.
Navigating Supplier Data
Whether you are looking for Rgd Peptide, CAS No. 99896-85-2 f RGD peptide (GRGDNP) (CAS 114681-65-1) rom a local distributor or sourcing a high-purity RP20297 catalog item, always request the Certificate of Analysis. The No. (number) is not just a label; it defines the synthesis path. For example, some RGD variants are modified with thiol groups for immobilization on polymers, which may alter the standard CAS classification.
* Integrin resear [3] In addition, RGD peptide can inhibit ACK-2 activation through cell adhesion. Cas No. 99896-85-2. Smiles, N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(O)= ch often requires the use of these tools without interference from impurities.
* Always ensure the CAS matches your protocol requirements, especially when transitioning between the tripeptide and the GRGDNP hexapeptide.
* Check for variations like CAS No.: 99891-77-7 or 99873-43-5 if your specific research involves branched or modified peptides.
By focusing on the specific CAS documentation and understanding the molecular differences between these RGD peptide sequences, you can ensure that your experimental setup remains consisten May 29, 2024 — Contains the motif RGD (Arg-Gly-Asp) which is found in many integrin ligands. Inhibits cell adhesion of COS-7 cells to fibronectin 80-90% at 1mM. t and reproducible. Always verify the CAS Number: 114681-65-1 or the CAS number 99896-85-2 against the manufacturer’s data sheet before proceeding with your application.