In the specialized field of immunology research, the SLLMWITQC peptide holds a significant position as a well-characterized epitope. Derived from the New York esophageal squamous cell carcinoma 1 (NY-ESO-1) protein—a prominent cancer/testis antigen found in *Homo sapiens*—this nonapeptide has become a standard tool for scientists studying cellular interactions and MHC-restricted responses.
Understanding the SLLMWITQC Peptide Structure
The SLLMWITQC peptide (157-165) is a linear peptidic epitope that functions as an essential component in biochemical assays. My experience with this specific sequence highlights its utility in studying HLA-A*0 A recombinant nonapeptide used as an antineoplastic vaccine. NY-ESO-1bpeptidevaccine contains the amino acid sequenceSLLMWITQC, derived from the Read more 2:01 restricted interactions. Because it is a WT NY-ESO-1/HLA*02:01-restricted peptide, SLLMWITQC, it serves as a reliable model for researchers examining how specific antigens are presented by the MHC Class I complex.
When investigating this molecule, one must consider its structural integrity. Crystal structure analysis of the NY-ESO-1 epitope, SLLMWITQC, has provided detailed insights into how it binds within the HLA-A2 groove, a critical step for molecular modeling and assay validation.
Research Applications and Assay Utility
The Antigen Peptide NY-ESO-1 - HLA-A*0201 (SLLMWITQC) is frequently utilized in high-precision laboratory settings. I have observed that its primary role involves:
Antigen Peptide NY-ESO-1 - HLA-A*0201 (SLLMWITQC)* Antigen-specific stimulation: It is instrumental in T-cell assays, including ELISPOT and intracellular cytokine staining (ICS).
* MHC Complex Studies: The Biotinylated Human HLA-A*02:01&B2M&NY-ESO- HLA-A*02:01 NY-ESO-1 Tetramer-SLLMWITQC-APC 1 (SLLMWITQC) complex protein is a sophisticated reagent often used in flow cyt The Human HLA-A*0201 NY-ESO-1 (SLLMWITQC) complex protein is a complex of HLA-A*0201 of the MHC Class I, B2M andSLLMWITQC peptideof the NY-ESO-1. 제품 Read more ometry to identify antigen-specific populations.
* Sensitivity Tools: For those requiring maximum detection sensitivity, peptide-loaded MHC MACSimers offer a robust platform for reliable data collection.
Whether you are using a standard peptide or a specialized construct such as the SLLMWITQC + AIB(C9) variant, consistency is key. The 157-165 SLLMWITQC region is highly conserved, making it a focal point for those studying the NY-ESO-1/LAGE-1-derived SLLMWITQC peptide interactions in various models.
Comparative Studies and Analogs
In my review of available materials, I’ve noted that researchers often compare the wild-type sequence with analogs. For instance, the NY-ESO-1 (157-165) C165V SLLMWITQV is a common alternative. While SLLMWITQC is the benchmark, the single peptide (SLLMWITQV) is also widely used for the stimulation of human CD8+ T-cells where specific binding affinities are being tested.
Furthermore, the NY-ESO-1 SPEAR T cells pr SLLMWITQV epitope - Immune Epitope Database (IEDB) oduced cytokines in response to antigen-specific stimulation using the SLLMWITQC sequence, demonstrating the biological relevance of this epitope in controlled laboratory environments. This highlights why it is classified as a class, class I, animal species, human reagent—its applicability across various humanized test systems is extensive.
Concluding Thoughts on Technical Integration
Whether you are utilizing a recombinant human single-chain TCR (scTCR) 1G4 to detect the epitope or conducting topical peptide immunization with NY-ESO-1B peptide (SLLMWITQC), the precision of the peptide source is paramount. As SLLMWITQC, an NY-ESO-1-derived peptide, continues to be a subject of intense NY-ESO-1 Peptide (SLLMWITQC) study, i by V Dutoit·2002·Cited by 135—Three peptides corresponding to overlapping sequences spanning the 155-167 region of the protein (155-163 QLSLLMWIT,157-165 SLLMWITQC, and 157-167 Read more t remains a cornerstone for understanding the fundamental mechanisms of the tumor cell antigen found in various types of cancers.
For anyone working with the HLA-A*02:01 negative tetramer-APC or similar conjugates, the SLLMWITQC from Homo sapiens (human) NY-ESO-1 protein remains the gold standard for verifying experimental accuracy in non-clinical research. Always ensure that your inventory of NY-ESO-1 peptide (SLLMWITQC) is sourced from reputable providers to maintain the integrity of your peptide-based investigations.