In the evolving field of peptide research, few compounds have garnered as much scientific attention as the SS-31 (peptide). Often referred to by various designations in literature and clinical develo by Y Zhu · 2018 · Cited by 81 — SS-31 (D-Arg-Dmt-Lys-Phe-NH2; Dmt-2′,6′-dimethyltyrosine) is a novel mitochondria-targeted peptide [20, 21]. It can penetrate the brain-blood barrier and then pment by Y Zhu · 2022 · Cited by 73 — Among them, D-Arg-Dmt-Lys-Phe-NH2 (SS-31, also known as MTP-131, elamipretide It has also been suggested that SS-31 ameliorates LPS-induced nucleus , the molecule is frequently discussed as SS-31, also known as Elamipretide. Understanding the nomenclature and the underlying biochemistry is essential for anyone interested in how these synthetic compounds interact with cellular structures.
Understanding the Nomenclature: What is SS-31?
When exploring the landscape of mitochondrial research, you will encounter several names for this specific tet Beneficial effects of SS-31 peptide on cardiac rapeptide. Whether you see it labeled as MTP-131, Bendavia, or Elamipretide (aka SS31), these terms all point to the same synthetic molecule: D-Arg-Dmt-Lys-Phe-NH2. It belongs to the Szeto–Schiller (SS) peptides family, a group of amphipathic molecules designed to penetrate cell membranes effectively.
SS 31 (Elamipretide) is primarily recognized for its unique ability to localize wit SS-31 Peptide | Cellular Energy & Repair hin the inner mitochondrial membrane. Unlike many other compounds, it selectively binds to cardiolipin, a phospholipid essential for the structural integrity and optimal function of the mitochondria. By stabilizing this interaction, the peptide helps maintain the efficiency of the electron transport chain.
Mechanism and Cellular Function
The primary interest in this compound stems from its role as a scavenger of reactive oxygen species (ROS) scavengers. Mitochondria are the primary sites of ROS production, and when these levels become imbalanced, it can SS-31, also known as MTP-131, elamipretide and Bendavia, is a unique tetrapeptide that specifically targets the mitochondria within cells. lead to cellular stress. By functioning as a scavenger, the peptide helps mitigate the accumulation of these oxidative byproducts.
For researchers studying cellular energetics, Elamipretide (SS-31) represents a breakthrough in understanding how we might support mitochondrial health. Its structure—specifically the inclusion of dimethyltyrosine (Dmt)—is what allows it to cross membranes and exert its protective effects. You will often see it discussed alongside other research peptides like Epitalon, though its primary mechanism of targeting the inner mitochondrial me by S Russo · 2022 · Cited by 28 — Our results indicate that SS-31 have beneficial effects on improving cardiac mitochondrial dysfunction in a BTHS animal model. mbrane sets it apart.
Research Context and Industry Development
It is important to note that Elamipretide has been explored extensively in various models. For instance, you may find documentation regarding its use as a medication used for the treatment of Barth syndrome, reflecting its significance in rare metabolic research. Organizations like Stealth BioTherapeutics have been at the forefront of this development, often utilizing the c SS 31 (Elamipretide) is a groundbreaking peptide developed to target and support mitochondrial function, a crucial element of cellular health. ode MTP-131 in early-stage trials.
When searching for information, you will encounter terms such as Bendavia, Elamipretide, and MTP-13, which are often used interchangeably in scientific databases. Whether referred to as MTP-131, elamipretide and Bendavia or simply SS-31, the core investigation remains consistent: how can we optimize the mitochondrial landscape?
Personal Perspectives in Peptide Research
In my own exploration of these compounds, the precision of the SS-31 structure—a small, highly specific tetrapeptide—is what makes it a fascinating subject for stu by MT Sweetwyne · 2017 · Cited by 120 — Elamipretide (SS-31) is a mitochondria-targeted tetrapeptide that selectively interacts with cardiolipin on the inner mitochondrial membrane. SS-31 enhances dy. Unlike generic supplements, this compound demonstrates a targeted approach to cellular maintenance. Whether it is labeled as Bendavia or elamipretide, the consistency of its chemical structure ensures that researchers can rely on its predictable behavior in laboratory settings.
For those tracking the latest developments, the transition from experimental codes like MTP or 31 to more standardized clinical terminology like Elamipretide marks the maturity of this field. As we continue to look into the SS series of peptides, the focus remains on the structural and functional integrity of the mitochondria, the powerhouse of the cell.
Summary of Key Identifiers
* Primary Name: SS-31
* Aliases: Elamipretide, MTP-131, Bendavia
* Classification: Szeto–Schiller tetrapeptide
* Function: Mitochondrial-targeted cardiolipin interaction and ROS scavenging.
By keeping these identifiers in mind, you can better navigate the complex literature surrounding SS-31 (also known as Elamipretide). As research progresses, the clarity provided by these consistent naming conventions will undoubtedly assist in the further understanding of mitochondrial-targeted therapeutics.