In the rapidly evolving field of synthetic biology and materials science, the VPM peptide has emerged as a cornerstone for researchers focused on creating sophisticated, stimuli-responsive systems. As an enthusiast who follows the latest developments in laboratory-grade re Influencers are promoting peptides for better health. What agents, I have found that understanding the technical specifications of such tools is essential for grasping how modern hydrogel engineering is pushing the boundaries of tissue scaffold design.
What is VPM Peptide?
VPM peptide TFA | Peptide Cross-LinkerAt its core, VPM peptide is a specialized, protease-cleavable dithiol cross-linker. Its primary structural identity is defined by the sequence GCRDVPMSMRGGDRCG (VPM). This specific amino acid sequence is not arbitrary; it is meticulously designed to be recognized and degraded by matrix metalloproteinases (MMPs), such as MMP-1 and MMP-2.
Because VPM peptide functions as a protease-cleavable dithiol cross-linker, it is frequently employed in the development of synthetic extracellular matrix (ECM) mimics. The molecular formula for this compound is C63H109N25O22S4, with a molecular weight typically recorded around 1696.96 Da. When analyzing the Product Name : VPM peptide, one must note its high purity requirements, often exce by L Lin·2014·Cited by 42—To mimic the properties of extracellular matrix, both cell-adhesivepeptide(GRGDSP) and matrix metalloproteinase (MMP) sensitivepeptide(VPMSMRGG or GPQGIAGQ) Read more eding 99% for reliable experimental outcomes.
Applications in Hydrogel Engineering
One of the most fascinating aspects of my research into this field is how PEG-4A and PEG-4VS were cross-linked with VPM peptide to create 3D hydrogels. By incorporating this sequence into the backbone of PEG-diacrylate (PEG-DA) or multi-arm PEG macromers, scientists can create materials that respond to their biological environment.
This functionality means the resulting hydrogel is not a static structure; rather, it is a dynamic scaffold that can be used to study cell migration and matrix remodeling. In these environments, cellular activity triggers the enzymatic degradation of the cross-links, allowing for the pr VPM-p15 peptide ecise spatial and temporal control of cell-mediated matrix reconstruction.
Distinctions: VPM vs. VPM-p15
It is crucial to distinguish between the standard cross-linker and its variants. For instance, VPM-p15 is a peptide agonist that serves a completely different purpose. While the standard VPM peptide is used for structural cross-linking, VPM-p15 is a useful tool to investigate the function of ADGRG2, an adhesion G protein-coupled receptor (also known as GPR64 or HE6) that plays a role in ion and pH homeostasis. These two products, while sharing a naming convention, serve distinct roles in the laboratory.
Maleimide Cross-Linked Bioactive PEG Hydrogel ExhibitsResearch Integrity and Usage Guidelines
When exploring the world of biochemistry, it is important to maintain a clear focus on the intended scope of these mat Mar 26, 2026—Peptidetherapies for wellness and longevity are popular, but safety concerns led the FDA to place more stringent requirements on them. erials. All products are “FOR RESEARCH USE ONLY” and are not intended for human therapeutic, diagnostic, or dietary applications.
There is a growing trend where injecting these molecules for athletic performance, longevity and more is discussed in popular media; however, it is vital to emphasize that the scientific literature—specifically regarding the VPM peptide—is strictly focused on *in vitro* a by EA Phelps·2012·Cited by 694—PEG-4A and PEG-4VS were cross-linked with VPM peptidefor 1 hour in TEA (400 mM). PEG-4MAL was cross-linked with VPM peptide for 10 min in 4 mM Read more nd *ex vivo* biochemical applications. The VPM peptide TFA (trifl Protease-degradable hydrogels with multifunctional uoroacetate) salt form, often found in catalogs, is intended for controlled laboratory settings where precise chemical properties are required to ensure the reproducibility of data.
Summary of Technical Specifications
For those interested in the technical nuances of this peptide, here is a brief summary of the key identifiers:
* Sequence: GCRDVPMSMRGGDRCG
* Primary Function: Protease-cleavable dithiol cross-linker
* CAS Number: 1428885-83-9
* Key Application: Creation of degradable hydrogels for tissue engineering
By focusing on these specific, measurable parameters, researchers can continue to utilize these tools to advance our understanding of complex biological systems. Whether you are working with hydrogel film formation or investigating the nuances of G protein-coupled receptors, the high specificity of the VPM sequence remains an indispensable component of the modern biotech toolkit.