In the expansive field of biochemical research, the Laminin Pentapeptide YIGSR-NH2 stands out as a critical tool for those investigating extracellular matrix (ECM) interactions. As someone who follows the latest developments in synthetic chemistry and cellular biology, I have closely examined the utility of this specific sequence—Tyr-Ile-Gly-Ser-Arg-NH2—and its profound impact on experimental models.
Defining the Entity: YIGSR-NH2
The YIGSR-NH2 molecule is a synthetic pentapeptide derived from the laminin beta 1 chain (specifically residues 929-933). Often referred to as a Laminin Peptide YIGSR-NH2, this sequence is a cornerstone for researchers studying cell-m Jan 12, 2009—This paper describes the synthesis and biological evaluation ofsix partial retro-inverso peptidomimetic analogs of YIGSR-NH2, atrix adhesion. The addition of the amide group (NH2) is a structural modification that influences the stability and biological activity of the peptide.
From a technical perspective, the molecule (CAS 110590-65-3) possesses a molecular weight of approximately 593.68 g/mol. Its high-purity profile, often exceeding 98%, ensures that observations in the lab are consistent and reliable.
Key Obs by Y Iwamoto·1987·Cited by 697—Further- more, thesepeptidesdid not inhibit lung tumor colonization by altering the tumori- genicity of the cells. The weight of tumors which formed 14 days Read more ervations and Research Applications
My interest in this YIGSR peptide stems from its unique ability to modul by Y Iwamoto·1987·Cited by 697—Further- more, thesepeptidesdid not inhibit lung tumor colonization by altering the tumori- genicity of the cells. The weight of tumors which formed 14 days Read more ate the cellular microenvironment. Here is what the research consistently highlights:
* Cellular Adhesion and Signaling: The YIGSR sequence acts as a ligand for the 67kDa laminin receptor. By facilitating specific binding, it allows for the precise study of how cells interact with their surroundings.
* Fibroblast Activity: A notable finding is that this compound increases collagen type 1 synthesis in fibroblasts, which makes it a subject of interest for those examining structural protein production.
* Inhibitory Potential: YIGSR-NH2 seems to inhibit the invasiveness of melanoma cells in vitro. Furthermore, studies have demonstrated that it has an inhibitory effect on tumour growth and metastasis in specific experimental models, providing a pathway for understanding complex cellular migration.
* Advanced Hydrogel Systems: Beyond simple liquid-phase experiments, VitroGel YIGSR High Concentratio A supramolecular hydrogel based on the combination of n represents the cutting edge of 3D cell culture. By incorporating this sequence into hydrogels, scientists can create more physiological environments for cell growth.
Comparative Analysis and Structural Analogues
When reviewing literature, one often encounters six partial retro-inverso peptidomimetic analogs of YIGSR-NH2. These variations are designed to improve resistance to enzymatic degradation, which is a common challenge with linear peptides. While the original Laminin Pentapeptide, amide;YIGSR-NH2 remains the standard, these analogs allow for longer-duration studies in serum-containing environments.
Practica VitroGel® YIGSR hydrogel for 3D cell culture l Considerations for Researchers
When sourcing Laminin Pentapeptide YIGSR-NH2 Active Peptide, quality control is paramount. Authentic samples should exhibit the correct molecular weight and high solubility in water. Because this is a research-grade tool, proper storage—typically at -20°C—is essential to maintain the integrity of the Pentapeptide YIGSR structure.
Conclusion: Why YIGSR-NH2 Matters
Whether you are exploring the nuances of the YIGSR (Laminin Fragment 929-933) or assessing its role in modulating the extracellular matrix, the consistency of this pentapeptide makes it an indispensable asset. It is not merely a reagent; it is a fundamental piece of the puzzle in understanding how cells navigate, adhere, and respond to their structural environment.
For those conducting a Yigsr nh2 peptide review or performing a Yigsr nh2 peptide test, t Laminin Pentapeptide YIGSR-NH2; Manufacturer: 4194 ; List Price: 1,048.00 USD ; Overview / Applications · This product is for research use only. Do not administer Read more he data confirms that this sequence continues to be a gold standard for researchers aiming to push the boundaries of current biological knowledge. By focusing on the specific interactions facilitated by this peptide, the scientific c by M Zhao·1997·Cited by 15—This paper describes the synthesis and biological evaluation of six partial retro-inverso peptidomimetic analogs ofYIGSR-NH2, a synthetic peptide from the beta Read more ommunity continues to gain clarity on the complex signaling pathways that govern cell behavior.