Sixteenth-Century Child Diagnosed With Hepatitis B

News January 5, 2018

(Gino Fornaciari, University of Pisa)
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Hepatitis B virus
(Gino Fornaciari, University of Pisa)

HAMILTON, CANADA—Hendrik Poinar of McMaster University and Edward Holmes of the University of Sydney led an international team of scientists who have sequenced the complete genome of a strain of hepatitis B dating back hundreds of years, according to a report in The Star. They obtained the sample of the virus from the naturally mummified body of a two-year-old girl kept in the sacristy of the Basilica of Saint Domenico Maggiore in Naples, Italy. It had been thought the child had died of smallpox, due to the rash-like scars on her face and body. When the researchers failed to find any genetic evidence of smallpox in the samples of the child’s skin and bones, they looked for a genetic match with other disease-causing organisms. The test results suggest she may have suffered from Gianotti-Crosti syndrome, a rare childhood disease that can follow hepatitis B infection. “That’s a rash that breaks out extensively on children and it can cause death,” Poinar said. The scientists also found that the sixteenth-century strain of hepatitis B virus differed very little from modern-day iterations of the virus. For more, go to “Diagnosis of Ancient Illness.”

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